Methyl prednisolone sodium succinate

• Class: Gluco corticoid
• Action: Unbound glucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic receptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The anti-inflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Methyl prednisolone sodium succinate is a soluble form of methyl prednisolone intended for acute therapy when high IV doses are needed for rapid effect.
• Indications: Shock, CNS trauma
• Dosage:               IV

               Dog: 30 mg/kg; 2 hours later give 15 mg/kg
               Horse: 10 - 20 mg/kg