Levamisole

• Class: Imidothiazole anthelmintic
• Action: It stimulates the parasympathetic and sympathetic ganglia in susceptible worms. At higher levels, it interferes with nematode carbohydrate metabolism by blocking fumarate reduction and succinate oxidation. The net effect is a paralyzing effect on the worm which is then expelled alive. Its effects are considered to be nicotine-like in action. Its mechanism of action for its immunostimulating effects are not well understood. It is believed it restores cell-mediated immune function in peripheral T-lymphocytes and stimulates phagocytosis by monocytes. Its immune stimulating effects appear to be more pronounced in animals that are immune-compromised.
• Indications: Nematodal infestations, to stimulate immune response, Microfilariasis in dogs.
• Dosage:               Oral, SC

                Animals

                       Treatment: 7.5 mg/kg

                       Immunostimulant: 2.5 mg/kg

               Dog

                      Microfilaricidal: 10 mg/kg PO once a day for 6-10 days

                      Hookworms: 5-8 mg/kg Oral once

                      Immunostimulant: 0.5 - 2 mg/kg 3 times a week

             

               Cat

                      Lung worms: 20-40 mg/kg PO once a day for 5 days

                      Immunostimulant: 0.5 - 2 mg/kg

• INTAMISOL-L               Intas

               Bolus          1 gm          4's

• ISD               Virbac

               Poultry

                    De-worming dose: 30 mg/kg BW through drinking water

                                           100 gm/ 1000 growers (Avg 1 Kg)

                                           150 gm/1000 layers

                   Immunostimulatory dose: 15 mg/kg  through drinking water

                                                               50 g for 1000 growers (Avg 1 Kg)

                                                               75 g for 1000 layers 

             

                   Powder          30% w/w          500 gm 

• MYSOL               Vetindia

                  Powder          10% w/w          25 gm
                  Powder          30% w/w          100 gm, 200 gm, 500gm

• NEMATEX-L               Neospark

                 Poultry

                      Layers: 50 gm/50 L drinking water/500 layers after starving for a few hours

                      Chicks: 50 gm/50 L drinking water/1000 chicks after starving for a few hours.

                 Bolus          2.190 gm          24's 

                 Powder          30% w/w          50 mg, 100 mg, 500 mg