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Thursday, 12 May 2016

Human Chorionic Gonadotropin

  • Class: Non pituitary gonadotropin
  • Action: It mimics the effects of luteinizing hormone (LH), but also has some FSH-like activity. In males, HCG can stimulate the differentiation of, and androgen production by, testicular interstitial (Leydig) cells. It may also stimulate testicular descent when no anatomical abnormality is present. In females, HCG will stimulate the corpus luteum to produce progesterone, and can induce ovulation (possibly also in patients with cystic ovaries). In the bitch, HCG will induce estrogen secretion.
  • Indications & Dosage:
                 Repeat breeding:
                         Cattle: 1500-3000 IU as IM
                         Sheep, Goat: 200-500 IU on the day or before service
                         Dog: 100-500 IU on the day of service
                 Cystic ovaries:
                         Cattle: 1500-3000 IU as IV
                         Horse: 1500-5000 IU as IM
                 Delayed ovulation:
                         Cattle: 1500-3000 IU as IM, repeat on day 8, if CL is poorly developed
                 Post Partum Lactation failure:
                         Horse: 1500-3000 IU in every 24 hr along with synthetic oxytocin
                         Dog: 100-500 IU in combination with synthetic oxytocin
                 Foetal resorption, Early abortion: 
                         Cattle:1500-3000 IU/week for 4 weeks as IM
                         Sheep, Goat: 100-500 IU as IM
                         Dog: 200-500 IU as IM
  • CHORULON               MSD
                 Inj          1500 IU