Neostigmine

• Class: Quaternary ammonium parasympathomimetic agent
• Action: It competes with acetylcholine for acetylcholinesterase. As the neostigmine acetylcholinesterase complex is hydrolyzed at a slower rate than that of the acetylcholine- enzyme complex, acetylcholine will accumulate with a resultant exaggeration and prolongation of its effects. These effects can include increased tone of intestinal and skeletal musculature, stimulation of salivary and sweat glands, bronchoconstriction, ureter constriction, miosis and bradycardia. It also has a direct cholinomimetic effect on skeletal muscle.
• Indications: Myasthenia gravis, Rumen atony, Urinary retention
• Dosage:

               Dog:  0.05 mg/kg SC OD or 0.04 mg/kg SC/IM four times daily