Ivermectin

• Class: Avermectin derivative ectendoparasiticide
• Action: It enhances the release of GABA at presynaptic neurons. GABA acts as an inhibitory neurotransmitter and blocks the post-synaptic stimulation of the adjacent neuron in nematodes or the muscle fiber in arthropods. By stimulating the release of GABA, ivermectin causes paralysis of the parasite and eventual death. As liver flukes and tapeworms do not use GABA as a peripheral nerve transmitter, ivermectin is ineffective against these parasites.
• Indications: Nematodal infections (GI nematodes, eye worms, lung worms), ectoparasites like tick, lice, mites and nasal bots in sheep and goat, cutaneous myasis, demodectic mange, larval stages of canine heart worm disease (microfilaria)
• Dosage:               SC, Oral

                Cattle, Sheep, Goat, Horse, Pig, Dog: 200 mcg/kg

• Precautions: Ineffective against trematodes, cestodes and adult canine heart worms. Toxic to certain breeds of dogs like Collie.

• AVERTIN               Neospark

                Oral Soln          0.08% w/v          100 ml, 250 ml, 500 ml
                Powder          1% w/w          5 gm

• HITEK               Virbac

                Inj          10 mg/ml          1 ml, 10 ml, 30 ml

                Oral Soln          0.08% w/v          100 ml, 1 L

                Powder          1% w/v          100 gm

                Tab          80 mg          1's  

• HITEK PLATINUM               Virbac

                Inj          31.5 mg/ml          10 ml

• NEOMEC               Intas

                Inj          10 mg/ml          1 ml, 7 ml, 10 ml, 20 ml, 50 ml

                Oral Soln          0.08% w/v          100 ml, 500 ml, 1 L

                Tab          10 mg          5's

                Tab          10 mg          10's

• TRUMECTIN               Zydus AHL

                Inj          10 mg/ml          10 ml

                Oral Soln          0.08% w/v          100 ml, 500 ml, 1 L